Image copyright Sky News Leaving the EU would lead to more jobs, a "non-racist" immigration policy and allow the government to help the steel industry, Michael Gove has said.
In a live Q&A, the pro-Leave justice secretary urged voters to "take back control" from "Europe's elites".
He was pressed on his campaign's controversial claim that £350m a week is spent on the EU.
The Remain side said he had "failed to set out a credible plan for Britain outside the EU".
After the Sky News interview, the Leave campaign said an extra £100m - saved by quitting the EU - should be spent on the NHS.
Live: Reaction to Michael Gove's interview
The UK's EU referendum takes place on 23 June.
The Sky News interview followed Thursday night's show which had a similar format but featured Prime Minister David Cameron, who is campaigning for Remain.
Mr Gove criticised the prime minister's performance, describing it as "depressing" and "an exercise in trying to scare you".
- Would Brexit put jobs at risk?
- Are we giving £350m a week to Brussels?
- Would a points-based immigration system work for the UK?
- Read more from Reality Check
Challenged on the lack of international leaders and organisations backing his side, he said the public had "had enough of experts" saying "they know what is best and getting it consistently wrong".
He repeatedly targeted the "elites" of the EU and criticised their "invincible arrogance".
Questioned on the £350m figure, which has been criticised by the chairman of the UK Statistics Authority, Mr Gove said he was "happy" to have the claim independently audited and described it as "the difference between the total amount we hand over and what we get back".
The important thing, he said, was "we don't have control of that money".
Why this issue matters What the leave and remain sides are saying about the cost of membership in the #EUref campaignThe debate
- The UK is a net contributor to the EU budget
- The gross contribution in 2015 was £17.8bn but the UK rebate was worth £4.9bn
- £4.4bn was also paid back to the UK government for farm subsidies and other programmes
Leave
- The gross cost works out at £350m a week
- If the UK left, billions of pounds would become available for other priorities
- The UK would also be able to decide how to spend the money that the EU transfers back to it
Remain
- Economic benefits of EU membership easily outweigh the cost
- Other countries contribute more per person than the UK does
- After Brexit, the UK would still have to contribute to the EU budget to retain access to the single market
The justice secretary described the EU as a "job-destroying machine" but also said: "I can't guarantee every person currently in work in their current job will keep their job."
Earlier JP Morgan warned it may have to cut up to 4,000 UK jobs if there is a vote to leave the EU.
Vote Leave have been campaigning hard on immigration in recent days, and Mr Gove said that by leaving, the UK could have an "inclusive, non-racist immigration policy that works in the interest of everyone in this country".
He faced several hostile questions from the audience, with one man comparing him to a World War One general sending his soldiers "over the top" with "no idea what's on the front line".
Responding to a Port Talbot steel worker who asked how he should vote to protect his job, Mr Gove said leaving the EU would allow the government "additional flexibility" to step in and support struggling industries.
Shadow justice secretary and Remain campaigner Lord Falconer said the interview was a "lost opportunity" because Mr Gove had not explained "the economics of leaving".
Why this issue matters What the leave and remain sides are saying about sovereignty and laws in the #EUref campaignThe debate
- The UK has to apply EU directives. EU regulations are binding across all member states
- EU laws are proposed by the European Commission and most of them must be agreed by at least 16 national governments representing 65% of the EU population as well as the European Parliament
- EU laws are enforced by the European Court of Justice (ECJ)
Leave
- Most UK laws are made in Brussels
- Other member states can force through decisions against the UK’s wishes
- The British government has repeatedly been defeated in cases brought to the ECJ
- Leaving the EU is the only way to regain full sovereignty
Remain
- Only a minority of UK laws derive from the EU
- Britain retains a veto in many important areas
- Cameron’s EU deal allows national parliaments to block legislation
- Some sharing of sovereignty is crucial to enable fair trade across Europe
He added: "I thought it was a very, very telling hour because it revealed that there is no answer to what practically every economist said which is that we would suffer terribly economically if we left the EU."
The Stronger In campaign highlighted Mr Gove's comment about people keeping their jobs, and said Leave could not "name a single expert, economic institutions, business or foreign ally who supports them quitting Europe".
Mr Cameron, whose party is split on the EU, has refused to take part in any head-to-head TV debates with fellow Conservatives who back leaving the union.
But a number of debates and live Q&As are planned, including the BBC's event at Wembley Arena on 21 June.
In his appearance, the PM was pressed on immigration from within the EU, warning that voting to Leave in order to try to control it would "trash" the economy.
What TV debates are planned, and when?
BBC:
- A live event at Wembley Arena on 21 June with representatives of both sides of the EU debate questioned by voters. David Dimbleby, Mishal Husain and Emily Maitlis to present.
- Two special editions of Question Time, moderated by David Dimbleby - with Michael Gove on 15 June in Nottingham and David Cameron on 19 June in Milton Keynes
- A young voters' show from Glasgow was held on 26 May, presented by Victoria Derbyshire
ITV
- David Cameron and Nigel Farage will in turn answer questions from a studio audience in a live programme on 7 June
- Live TV referendum debate between figures from both sides of the campaign on 9 June. Line-up yet to be announced
Sky
- Two live shows featuring David Cameron on 2 June and Leave campaigner and Justice Secretary Michael Gove on 3 June
- Each show includes a face-to-face live interview and a question-and-answer session in front of a studio audience
Channel 4
- Debate on 22 June, the day before the referendum, featuring "politicians, opinion formers and other high-profile pro and anti-protagonists"